Effect of repeated intra-cerebro-ventricular injections on conjugated dopamine antibodies on behavioral hypersensitivity in mice
Authors
O. Mrabet, C. Messier, M. K. Choulli, C. Destrade, M. GeffardFiles
Key Information
Journal
Published in Vol. 15 No. 1 (1995) of Moroccan Journal of Agricultural and Veterinary Sciences.
Multidisciplinary journal that publishes original research articles and literature reviews in the fields of agriculture, agronomy, rural engineering, topography, forestry, horticulture, food, nutrition, animal husbandry and veterinary science (online-ISSN: 2550-4401, print-ISSN: 2028-991X). Indexed by DOAJ, Google Scholar, Articles DOAJ, Mirabelle, ROAD, WorldCat
About the Journal
Abstract
ln the present study the effect ofrepeated intracerebroventricular (ICV) of anti-conjugated dopamine antibodies (Acm anti-DAc) was investigated on behavioural supersensitivity and eating behavior. Mice were injected in ICV (with an ICV cannula) with either Acm anti-DAc or no immuns immunoglobulins (IgNI) twice a week for 5 weeks, their behavioural supersensitivity to apomorphine (0.05 mglkg) were measured. The results showed that Repeated intracerebroventricular injections of anti conjugated dopamine antibodies produced a behavioural supersensitivity to apomorphine. Immunohistochemical analysis showed that the behavioural supersensitivity is not due to DA celllosses in the substantia nigra or the ventral tegmentum area.
Key words: Dopaminergic antibodies, Intracerebroventricular injections, Behavioural supersensitivity, Mice
References
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Revue Marocaine des Sciences Agronomiques et Vétérinaires est mis à disposition selon les termes de la licence Creative Commons Attribution - Pas d’Utilisation Commerciale - Partage dans les Mêmes Conditions 4.0 International.
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