Moroccan Journal of Agricultural and Veterinary Sciences

Vol. 12 No. 4 (2024): (December 2024)
Fishing and Fisheries

Ecotoxicity of zebrafish larvae exposure to EE2/A6 mixture: Special emphasis on the posterior lateral line, PLL

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  • Ahmed NASRI,
  • Hamouda BEYREM,
  • Ezzeddine MAHMOUDI,
  • Mireille ROSSEL,
  • Véronique PERRIER
Ahmed NASRI Laboratoire de Biosurveillance de l’Environnement, Unité d'Écologie et Écotoxicologie Côtières, Faculté des Sciences de Bizerte, Université de Carthage, Zarzouna, Tunisie
Hamouda BEYREM Laboratoire de Biosurveillance de l’Environnement, Unité d'Écologie et Eco toxicologie Côtières, Faculté des Sciences de Bizerte, Université de Carthage, Zarzouna, Tunisie
Ezzeddine MAHMOUDI Laboratoire de Biosurveillance de l’Environnement, Unité d'Écologie et Eco toxicologie Côtières, Faculté des Sciences de Bizerte, Université de Carthage, Zarzouna, Tunisie
Mireille ROSSEL Unité Mécanismes Moléculaires des Maladies Neurodégénératives, Institut National de la Santé et de la Recherche Médicale, Université de Montpellier, Montpellier, France
Véronique PERRIER Unité Mécanismes Moléculaires des Maladies Neurodégénératives, Institut National de la Santé et de la Recherche Médicale, Université de Montpellier, Montpellier, France

Published 2024-11-21

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Abstract

Posterior lateral line or PLL is a mechanosensory system present in fish and amphibians, which allows the detection of water movements in the environment. Stimulation of this system leads to an adapted behavioral response, such as swimming against the direction of the current, sexual display, detection of prey and predators. It has disappeared in terrestrial organisms and in particular in most tetrapods, where it has been replaced by another structure, the inner ear. The aim of our present study is to evaluate the effects of endocrine disruptor mixtures on zebrafish PLL regeneration. Exposure of 24-h-old larvae for 6 days to ethinylestradiol compounds EE2 and biopesticide A6 caused delayed nerve and hair cell regeneration. These results could lead to severe long-term effects on neuronal plasticity and repair and suggest that auditory hair cell loss is irreparable in mammals, especially in humans.

Keywords: Posterior lateral line (PLL), EE2/A6 mix, exposure, regeneration, nerve, hair cells

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References